Tailoring NK Cell Receptor-Ligand Interactions: An Art in Evolution

• Main Author: Gianfranco Pittari (auth)
• Other Authors: Antoine Toubert (auth), Ulrike Koehl (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; Natural Killer cells; Checkpoint inhibitors; Immune Evasion; Immunotherapy; Transplantation; chimeric antigen receptors; Nk receptors; bispecific antibodies; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activ...