Targeting PI3K/mTOR signaling in cancer

• मुख्य लेखक: Alexandre Arcaro (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2014
• श्रृंखला: Frontiers Research Topics
• विषय: Medicine; Phosphoinositide 3-kinase; mTOR; clinical trials; Akt; Cancer
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism. Deregulation of the PI3K pathway has been extensively investigated in connec...