Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

• Main Author: Changjun Yin (auth)
• Other Authors: Andreas J.R. Habenicht (auth), Pasquale Maffia (auth), Sarajo Mohanta (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Medicine; Autoimmunity; nonresolving peripheral tissue inflammation; Autoinflammation; Tertiary lymphoid organs; dichotomies of immune responses; disease immunity; Immune Tolerance; antigen
• Online Access: DOAB: download the publication; DOAB: description of the publication

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A bette...