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Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity

The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A bette...

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Bibliographic Details
Main Author: Changjun Yin (auth)
Other Authors: Andreas J.R. Habenicht (auth), Pasquale Maffia (auth), Sarajo Mohanta (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2017
Series:Frontiers Research Topics
Subjects:
Medicine
Autoimmunity
nonresolving peripheral tissue inflammation
Autoinflammation
Tertiary lymphoid organs
dichotomies of immune responses
disease immunity
Immune Tolerance
antigen
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Summary:The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
Physical Description:1 electronic resource (235 p.)
ISBN:978-2-88945-180-7
9782889451807
Access:Open Access

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