Thymic stromal alterations and genetic disorders of immune system

• Autor principal: Claudio Pignata (auth)
• Otros Autores: Ana E. Sousa (auth)
• Formato: Electrónico Capítulo de libro
• Lenguaje: inglés
• Publicado: Frontiers Media SA 2015
• Colección: Frontiers Research Topics
• Materias: Medicine; Central Tolerance; Rag defects; Combined immunodeficiency; DiGeorge Syndrome; Foxn1; medullary thymic epithelial cells; APECED
• Acceso en línea: DOAB: download the publication; DOAB: description of the publication

The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterat...