Thymic stromal alterations and genetic disorders of immune system

• Hoofdauteur: Claudio Pignata (auth)
• Andere auteurs: Ana E. Sousa (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Frontiers Media SA 2015
• Reeks: Frontiers Research Topics
• Onderwerpen: Medicine; Central Tolerance; Rag defects; Combined immunodeficiency; DiGeorge Syndrome; Foxn1; medullary thymic epithelial cells; APECED
• Online toegang: DOAB: download the publication; DOAB: description of the publication

The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterat...