Thymic stromal alterations and genetic disorders of immune system

• 第一著者: Claudio Pignata (auth)
• その他の著者: Ana E. Sousa (auth)
• フォーマット: 電子媒体 図書の章
• 言語: 英語
• 出版事項: Frontiers Media SA 2015
• シリーズ: Frontiers Research Topics
• 主題: Medicine; Central Tolerance; Rag defects; Combined immunodeficiency; DiGeorge Syndrome; Foxn1; medullary thymic epithelial cells; APECED
• オンライン･アクセス: DOAB: download the publication; DOAB: description of the publication

The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterat...