Transmucosal Absorption Enhancers in the Drug Delivery Field

• Main Author: Maher, Sam (auth)
• Other Authors: Illum, Lisbeth (auth), Casettari, Luca (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; chitosan; intestinal epithelial cells; ocular delivery; amphiphilic polymers; cornea; tight junction modulator; cyclodextrin; permeability; gemini surfactant; transferrin; compound 48/80; epithelial permeability; cervicovaginal tumors; nanoparticles; confocal laser scanning microscopy; safety; formulation; salcaprozate sodium; intestinal absorption; FITC-dextran; curcumin; block copolymers; nasal vaccination; whole leaf; brush border; ocular drug delivery; vaccine adjuvant; nanoparticle; nasal delivery; efflux; permeation enhancers; absorption enhancers; nose to brain delivery; small intestine; epithelium; CNS disorders; absorption modifying excipients; insulin; absorption enhancer; gel; intestinal delivery; thermogel system; Caco-2; biocompatibility studies; absorption enhancement; man; PN159; poorly absorbed drug; tryptophan; tight junction; oral macromolecule delivery; penetration enhancer; intestinal permeation enhancers; nanocrystals; simvastatin; nanomedicine; enterocyte; N-dodecyl-?-D-maltoside (DDM); cell-penetrating peptide; quaternization; KLAL; nasal; nasal permeability; transmucosal drug delivery; Caco-2 cells; mast cell activator; penetration enhancers; drug delivery; nose-to-brain; bioenhancer; polymeric micelles; mucoadhesion; cell-penetrating peptide (CPP); simulated intestinal fluid; vaginal delivery; nasal formulation; pharmacokinetic interaction; sodium caprate; clinical trial; transmucosal permeation; drug absorption enhancer; sugar-based surfactants; nanocapsules; imatinib; teriparatide; osteoporosis; hydrophobization; F-actin; combined microsphere; transepithelial electrical resistance; oral delivery; ocular conditions; metabolism; antimicrobial peptide; permeation enhancer; drug administration; antiepileptic drug; amino acid; in vivo studies; sodium cholate (NaC); epithelial transport; preclinical; nose to brain transport; pharmacokinetics; chitosan derivatives; ophthalmology; tight junctions; sheep; cationic functionalization; GLP-1; pulmonary; and liposome; cytochrome P450; claudin; P-glycoprotein; in situ hydrogel; mucoadhesiveness; PTH 1-34; Aloe vera; oral peptides
• Online Access: DOAB: download the publication; DOAB: description of the publication

Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most...