Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations

• Main Author: Alan S. Perelson (auth)
• Other Authors: Kathryn J. Wood (auth), Giorgio Raimondi (auth), Julia C. Arciero (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Medicine; systems biology; theoretical modeling; transplant immunology; biomarkers; big data and bioinformatics; transplant rejection; transplant tolerance; mechanistic models
• Online Access: DOAB: download the publication; DOAB: description of the publication

Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient's immune system will launch a massive immune attack that will ultimately d...