Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System

• Main Author: Ashok N. Hegde (auth)
• Other Authors: Fred W. van Leeuwen (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; proteasome; memory; neuroinflammation; neurodegenerative; synaptic plasticity; aging; deubiquitinating; Huntington's disease; Alzheimer's disease; glutamate receptors
• Online Access: DOAB: download the publication; DOAB: description of the publication

Proteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were...