Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response

• मुख्य लेखक: Kristijan Ramadan (auth)
• अन्य लेखक: Ivan Dikic (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2018
• श्रृंखला: Frontiers Research Topics
• विषय: Genetics (non-medical); Ubiquitin; genome stability; Ubiquitination; SUMO; DNA damage response; Sumoylation; Cancer
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR...