Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response

• Главный автор: Kristijan Ramadan (auth)
• Другие авторы: Ivan Dikic (auth)
• Формат: Электронный ресурс Глава книги
• Язык: английский
• Опубликовано: Frontiers Media SA 2018
• Серии: Frontiers Research Topics
• Предметы: Genetics (non-medical); Ubiquitin; genome stability; Ubiquitination; SUMO; DNA damage response; Sumoylation; Cancer
• Online-ссылка: DOAB: download the publication; DOAB: description of the publication

DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR...