Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response

• 1. Verfasser: Kristijan Ramadan (auth)
• Weitere Verfasser: Ivan Dikic (auth)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Frontiers Media SA 2018
• Schriftenreihe: Frontiers Research Topics
• Schlagworte: Genetics (non-medical); Ubiquitin; genome stability; Ubiquitination; SUMO; DNA damage response; Sumoylation; Cancer
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR...