Unconventional Anticancer Metallodrugs and Strategies to Improve their Pharmacological Profile

• Main Author: Contel, Maria (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; ?-? stacking; encapsulation; n/a; oxindolimine-metal complexes; cyclodextrin; platinum iodido complexes; distribution coefficient; antiproliferative activity; anticancer agents; nanotubes; ruthenium; platinum; Log kw; nanoparticles; drug discovery; metal complex; metallodrugs; isatin-derived ligands; anticancer drug; upconverting nanoparticles; pyridine benzimidazole; dendrimers; liposomes; thiophene; angiogenesis; micelles; HSA oxidation; platinum(IV); imaging; chromatographic lipophilicity parameter; amidophosphine; copper and iron chelators in cancer; Log P; biomacromolecules; bones; DNA cleavage; stopped-flow spectroscopy; silver; phosphonates; transmetalation; metallomics; MRI; fluorescence quenching; partition coefficient; gold fingers; anticancer; HSA binding; gold; ?0; targeting; metastasis; DNA interaction; antimigration; cytotoxicity; HPLC; ruthenium complexes; zinc finger proteins; Gold(III) complexes; aquaporins; antiproliferative; protein-DNA recognition; photoactivation; lipophilicity; cancer; 1-methylcytosine; PET
• Online Access: DOAB: download the publication; DOAB: description of the publication

For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (...