Understanding Crohn's Disease: Immunity, Genes and Microbes

• Main Author: Fernando Magro (auth)
• Other Authors: Nair Campos (auth), Amelia Sarmento (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Medicine; intestinal microbiota; mucosal immune system; Crohn's disease; T cells; gene polymorphisms; epigenetics; mutritional modulation
• Online Access: DOAB: download the publication; DOAB: description of the publication

Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifac...