Amyotrophic Lateral Sclerosis Recent Advances and Therapeutic Challenges

• Övriga skapare: Hegde, Muralidhar L. (Utgivare, redaktör, sammanställare)
• Materialtyp: Elektronisk Bokavsnitt
• Språk: engelska
• Publicerad: IntechOpen 2020
• Ämnen: Neurology & clinical neurophysiology
• Länkar: DOAB: download the publication; DOAB: description of the publication

A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors...