Characterization and Clinical Management of Dilated Cardiomyopathy

• Other Authors: Merlo, Marco (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; SCN5A; cardiac sodium channel; cardiac channelopathy; dilated cardiomyopathy; precision medicine; arrhythmias; atrial fibrillation; cardiomyopathy; heart failure; supraventricular arrhythmia; systolic dysfunction; tachycardiomyopathy; ventricular arrhythmia; left atrial strain; cardiac resynchronization therapy; muscular dystrophy; calcium; heart; gene therapy; phospholamban; Serca2a; mdx; oxidative stress; membrane stabilization; left ventricular noncompaction; congenital heart disease; congestive heart failure; non-ischemic cardiomyopathy; genetics; desmin; mitochondrial dysfunction; myopathy; whole exome sequencing; laminopathy; LMNA; biomarkers; troponin T; NT-proBNP; malignant ventricular arrhythmia; arrhythmic risk stratification; DNA methylation; alternative splicing; epigenetics; nonischemic dilated cardiomyopathy; cardiac magnetic resonance imaging; late gadolinium enhancement; long axis strain; left ventricle sphericity index; major adverse cardiovascular events; sex differences; left ventricular reverse remodelling; long-term outcomes; left ventricle non-compaction cardiomyopathy; cardiac magnetic resonance; titin; RNA binding motif protein 20 (RBM20); sarcomere; diastolic dysfunction; phosphorylation; non-sense mRNA decay; mammalian target of rapamycin (mTOR) complex-1; duchenne muscular distrophy; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis...