Aggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen

• Other Authors: Johansson, Anders (Editor), DiRienzo, Joseph M. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; Aggregatibacter actinomycetemcomitans; cagE; virB1; virB4; genotype; virulence; mRNA assay; quantitative ELISA; cell lysis assay; leukotoxin; JP2 genotype; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomic; adherence; endocarditis; fimbriae; JP2; periodontitis; taxonomy; core and accessory genes; average nucleotide identity; principal component analysis; keratins; organotypic gingival mucosa; A. actinomycetemcomitans; RNA-Seq; genomic islands; core genes; accessory genes; stress; nutrient limitation; differentially expressed genes.; lymphocytes; apoptosis; RTX toxin; localized aggressive periodontitis; LFA-1; leukotoxin (LtxA); endocytosis; n/a; JP2 clone of Aggregatibacter actinomycetemcomitans; JP2 in Caucasian; microbiological diagnosis; adjunctive antibiotics; localized aggressive periodontitis: animal studies: human studies; landscape ecology; damage/response framework; bacteremia; horseshoe crab; Origanum vulgare; essential oil; antimicrobial activity; minimum inhibitory concentration; minimal bactericidal concentration; cytotoxicity; leukotoxin neutralization; inflammasome; immune response; periodontal disease; proteomics
• Online Access: DOAB: download the publication; DOAB: description of the publication

Aggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence po...