Transition Metals in Catalysis The Functional Relationship of Fe-S Clusters and Molybdenum or Tungsten Cofactor-Containing Enzyme Systems

• Other Authors: Leimkühler, Silke (Editor), Magalon, Axel (Editor), Einsle, Oliver (Editor), Schulzke, Carola (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; CO dehydrogenase; dihydrogen; hydrogenase; quantum/classical modeling; density functional theory; metal-dithiolene; pyranopterin molybdenum enzymes; fold-angle; tungsten enzymes; electronic structure; pseudo-Jahn-Teller effect; thione; molybdenum cofactor; Moco; mixed-valence complex; dithiolene ligand; tetra-nuclear nickel complex; X-ray structure; magnetic moment; formate hydrogenlyase; hydrogen metabolism; energy conservation; MRP (multiple resistance and pH)-type Na+/H+ antiporter; CCCP-carbonyl cyanide m-chlorophenyl-hydrazone; EIPA-5-(N-ethyl-N-isopropyl)-amiloride; nicotinamide adenine dinucleotide (NADH); electron transfer; enzyme kinetics; enzyme structure; formate dehydrogenase; carbon assimilation; Moco biosynthesis; Fe-S cluster assembly; l-cysteine desulfurase; ISC; SUF; NIF; iron; molybdenum; sulfur; tungsten cofactor; aldehyde:ferredoxin oxidoreductase; benzoyl-CoA reductase; acetylene hydratase; [Fe]-hydrogenase; FeGP cofactor; guanylylpyridinol; conformational changes; X-ray crystallography; iron-sulfur cluster; persulfide; metallocofactor; frataxin; Friedreich's ataxia; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Iron-sulfur (FeS) centers are essential protein cofactors in all forms of life. They are involved in many key biological processes. In particular, Fe-S centers not only serve as enzyme cofactors in catalysis and electron transfer, they are also indispensable for the biosynthesis of complex metal-con...