Emerging Role of Lipids in Metabolism and Disease

• Other Authors: Pallottini, Valentina (Editor), Segatto, Marco (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; neutral sphingomyelinase; radiation; sphingomyelin metabolism; pathology; cell signaling; brain; adipose tissue; breast cancer; epinephrine; breast reconstruction; epicardial fat thickness; visceral fat thickness; high-sensitivity c-reactive protein; leptin; gender; female; hippocampus; frontal cortex; adiponectin; haptoglobin; lipocalin; BDNF; synaptic proteins; phosphatidylinositol 4,5-bisphosphate; phospholipase C; cholesterol; high-cholesterol diet; BET proteins; cell proliferation; epigenetics; HMGCR; JQ1; LDLr; lipid metabolism; SREBP; TMEM97; atherosclerosis; diabetes mellitus; cardiovascular disease; chronic inflammation; hyperglycemia; mutations; lipid; fatty acid; glyceride; steroid; phospholipid; oral drug absorption; prodrug; phospholipase A2 (PLA2); acid sphingomyelinase; SOD; liver; eicosanoids; ischemic stroke; ischemia; lipoproteins; polyunsaturated fatty acids; angiogenesis; high-density lipoprotein; endothelial cell; metabolism; metabolic reprogramming; pulmonary fibrosis; lipid mediators; sphingolipids; sphingosine-1-phosphate; sphingosine kinase 1; prostaglandins; lysophosphatidic acid; autotaxin; G-protein coupled receptors; lysocardiolipin acyltransferase; phospholipase D; oxidized phospholipids; DNA damage response; double strand breaks; ATM; ionizing radiation; metabolic stress; oxidative stress; p53; nuclear sphingolipids; lipophagy; lipolysis; lipid droplets; lipid storage diseases; lipid metabolism diseases; mTORC1; TFEB; Cholesterol; Fatty acids; Lipid mediators; Lipids; Lipophagy; Sphingolipids
• Online Access: DOAB: download the publication; DOAB: description of the publication

Even though initially considered as a passive means for storing energy, lipids are now regarded as multifaceted molecules with crucial structural and functional activities. For instance, some of them play essential roles as key components of cell membranes whereas others act as signaling molecules i...