Human African Trypanosomiasis (Sleeping Sickness) The Road to Elimination Revisited-Achievements and Remaining Challenges

• Andere auteurs: Burri, Christian (Redacteur)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Onderwerpen: Medicine; Epidemiology & medical statistics; (+)-spectaline; iso-6-spectaline; Trypanosoma brucei rhodesiense; autophagy; apoptosis; cross-talk; trypanosomosis; iron; transferrin; transferrin receptor; nutritional immunity; flagellar pocket; Human African Trypanosomiasis (HAT); mydriasis; neurological signs; eradication; re-emergence; human African trypanosomiasis; treatment; melarsoprol; adverse event; encephalopathy; human leukocyte antigen; association study; disease elimination; disease eradication; frontline workers; DR Congo; mobile screening; qualitative methods; sequelae; serology; oligosymptomatic HAT; product development partnerships; research and development; medical innovation; donor policy; African trypanosomiasis; sleeping sickness; trypanosoma brucei; drugs; drug resistance; history; human Africa trypanosomiasis; fexinidazole; home-based treatment; patient-centred care; Uganda; elimination; T. b. gambiense; g-HAT; T. b. rhodesiense; r-HAT; neglected tropical diseases; Trypanosoma brucei; drug discovery; high-throughput screening; blood-brain barrier; brain permeability; pharmacology; phenotypic drug screening; Haemoparasites; animal reservoirs; Trypanosoma growth inhibitors; chemotherapy; pafuramidine; acoziborole; African sleeping sickness; development of treatment; suramin; medical history; political history; clinical research; health system strengthening; South Sudan; diagnosis; symptoms; treatment-seeking; case detection; embodiment; expertise; serendipity; CATT positive serological suspects; active follow-up strategy; n/a
• Online toegang: DOAB: download the publication; DOAB: description of the publication

As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spect...