Cytobiology of Human Prostate Cancer Cells and Its Clinical Applications

• Other Authors: Ishii, Kenichiro (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; androgen receptor; docetaxel; cabazitaxel; castration-resistant prostate cancer; chemotherapy; P-glycoprotein; EPI-002; splice variant; prostate-specific antigen; androgen deprivation therapy; time to PSA nadir; fibroblasts; prostate cancer; androgen sensitivity; pirfenidone; TGFβ1; G1 cell cycle arrest; fibroblast growth factor; fibroblast growth factor receptor; obesity; inflammation; immune cells; cytokine; high-fat diet; KIFC1; docetaxel resistance; apoptosis; CW069; Caveolin-1; TP53-regulated inhibitor of apoptosis 1; tumour stroma; tumour microenvironment; fibroblast; CAF; resistance; radiotherapy; CCL2; CCL22; CCL5; migration; LSD1; epigenetics; autophagy; abiraterone; enzalutamide; testosterone; castration resistant prostate cancer; animal model; diet; fat; in vitro; in vivo; mouse; AKR1C3; hormone-naïve prostate cancer; immunohistochemistry; tissue microarray; androgen receptor dependency; fibroblast-dependent androgen receptor activation; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The number of males diagnosed with prostate cancer (PCa) is increasing all over the world. Most patients with early-stage PCa can be treated with appropriate therapy, such as radical prostatectomy or irradiation. On the other hand, androgen deprivation therapy (ADT) is the standard systemic therapy...