Lassa Fever Viral Replication, Disease Pathogenesis, and Host Immune Modulations

• Other Authors: Ly, Hinh (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Lassa virus disease (LVD); vaccine breadth; mimicry; B cell anergy; conserved antigens; Fc-gamma receptors; conformational antigens; broadly-neutralizing antibodies; focused immunity; dominant and subdominant epitopes; cross-restriction; Lassa virus; Z protein; late domain; PPXY; budding; release; matrix protein; phosphorylation; arenavirus; mass spectrometry; viral glycoprotein; viral entry; viral fusion; fusion protein; Lassa virus vaccine; ML29 vaccine; STAT-1-/- mice; Mopeia virus; interfering particles; Lassa fever; LASV; virus-host interactions; entry; replication; Lassa vaccine; replication-deficient MVA vector; VLP formation; single-dose efficacy; cell-mediated immunity; arenaviruses; viral hemorrhagic fevers; animal models; mammarenavirus; vaccine; virulence; pathogenesis; innate immunity; adaptive immunity; COVID-19
• Online Access: DOAB: download the publication; DOAB: description of the publication

Lassa virus causes Lassa fever disease in several countries in West Africa, where it is estimated to infect up to half million people causing roughly five thousand deaths each year. This deadly virus has also been introduced in multiple occasions into the western world, including the United States,...