Stem Cell Bioprocessing and Manufacturing

• Other Authors: Cabral, Joaquim M. S. (Editor), Lobato da Silva, Cláudia (Editor), Diogo, Maria Margarida (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; electrospinning; live-cell electrospinning; tissue engineering; cell seeding; high voltage; viability; allogeneic cell therapy; induced pluripotent stem cell; human embryonic stem cell; cell aggregate; expansion; differentiation; scalable manufacturing; scale up; single-use bioreactor; Vertical-Wheel; U-shaped vessel; computational fluid dynamics; shear stress; turbulent energy dissipation rates; homogeneous hydrodynamic environment; human pluripotent stem cells; hepatic cell lineages; hepatocyte differentiation; non-parenchymal liver cells; liver organoids; disease modeling; drug screening; olfactory ensheathing cells; spinal cord injury; neural regeneration; cell therapies; adipose stem cells; neurotrophic factors; growth factors; peripheral nerve injuries; fibrin nerve conduits; hydrogels; stem cells delivery; axonal regeneration; Schwann cells; stromal vascular fraction; stem cell; adipose-derived stem cell; infrapatellar fat pad; knee; arthroscopy; arthrotomy; bioreactor; hMSCs; microcarrier; bioprocess; embryonic stem cells; mesenchymal stromal cells; blood platelets; cell culture techniques; progenitor cells; human adipose stem cells (hASCs); serum- and xeno-free conditions; UrSuppe stem cell culture medium; autologous therapy; kinetic growth modeling; segregated and unstructured growth model; model predictive control; bio-process; cell growth; lactate; advanced therapy medicinal products; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. Howev...