Metastatic Progression and Tumour Heterogeneity

• Other Authors: Hollande, Fred (Editor), Merino, Delphine (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; clear cell renal cell carcinoma; tumor evolution; tumor ecology; intratumor heterogeneity; multisite tumor sampling; targeted therapy; uterine carcinosarcoma; endometrial carcinoma; metaplastic carcinoma; epithelial-to-mesenchymal transition; clonality; mutation; TP53; PI3K/AKT pathway; gene expression; miRNA expression; tumor microenvironment; interstitial pH; acidosis; tumor heterogeneity; magnetic resonance imaging; hyperpolarized 13C MRI; carbonic anhydrase; lactic acid; positron emission tomography; esophageal squamous cell carcinoma; precision medicine; natural killer cells; tumor mutation burden; immunotherapy; PET; heterogeneity; radiomics; radiopharmaceuticals; SUV; nuclear medicine; colon cancer; Wnt signaling; phenotypic plasticity; EMT; hybrid E/M; collective and single-cell migration; beta-catenin paradox; breast cancer; immune microenvironment; DCIS; ADH; mammary gland; cell fate; 3D cultures; organoids; signaling; single-cell RNAseq; tumor endothelial cell; metastasis; angiocrine factor; microsatellite instability; colorectal cancer; immune checkpoints; deficient mismatch repair; plasticity; biomechanics; circulating tumor cells (CTCs); extracellular vesicles; metastatic niche; epigenetics; CTC-clusters; single-cell analysis; cellular heterogeneity; circulating tumor cells; pancreatic cancer; epithelial mesenchymal plasticity; target discovery; review; genomics; intra-tumour heterogeneity; subclonal diversity; treatment resistance
• Online Access: DOAB: download the publication; DOAB: description of the publication

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors...