Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment

• Weitere Verfasser: Di Meo, Sergio (Herausgegeben von), Venditti, Paola (Herausgegeben von), Napolitano, Gaetana (Herausgegeben von)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Schlagworte: Research & information: general; Biology, life sciences; CTCL; apoptosis; cell viability; c-FLIP; XIAP; artemisinin; SH-SY5Y cells; hippocampal neurons; H2O2; AMPK pathway; atherosclerosis; sphingomyelin synthase 2; endothelial dysfunction; endoplasmic reticulum stress; β-catenin; insulin resistance; cancer; cardiovascular disease; neurodegenerative disorders; exercise; mitochondria; oxidative stress; PGC-1; Nrf2; UCPs; ROS; light; DNA damage; evolution; D-box; cavefish; Spalax; trimethylamine N-oxide; cardiomyocytes; cardiotoxicity; mitochondrial membrane potential; CORM-2; NADPH oxidase; AP-1; HO-1; Renal cell carcinoma (RCC); reactive oxygen species (ROS); glutathione (GSH) metabolism; cancer therapy; clear cell RCC; papillary RCC; chromophobe RCC; sarcopenia; reactive oxygen species; redox signaling; antioxidant supplementation; protein aggregation; redox; proteinopathy; peroxiredoxins; tumorigenesis; ROS scavengers; n/a
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that...