Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor

• Other Authors: Holzmann, Klaus (Editor), Marian, Brigitte (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; FGFR4; FGF19; gene regulation; cancer signaling; anticancer; FRS2; FGFR; NVP-BGJ398; LY2874455; sarcoma; cancer-associated fibroblasts; GPER; breast cancer; estrogen; FGFR1; FGF2; optogenetics; ERK; AKT; receptor kinase; neurite outgrowth; HEK293; PC12; fibroblast growth factor receptors; signaling; receptor cross-talk; coreceptor; membrane proteins; FGFR2; ERK1/2; phosphorylation; serine; negative feedback loop; cancer; prognosis; HCC; inhibitors; FGF; fibroblast growth factor; autocrine signaling; skin; melanoma; squamous and basal cell carcinoma; seborrheic keratosis; targeted therapy; resistance; structure; kinase inhibitor; gastric cancer; monoclonal antibody; small molecule; FGFR2c; autophagy; keratinocyte; MTOR; JNK1; review; malignant glioma; brain cancer; astrocytoma; Sprouty proteins; FGF-mediated signaling; tumor suppressor; tumor promoter; malignant pleural mesothelioma; overall survival; immunohistochemistry; infigratinib sensitivity; FGF8; FGF18; adenocarcinoma of the esophagogastric junction; neoadjuvant therapy; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a...