Actinomycetes The Antibiotics Producers

• Other Authors: Stegmann, Evi (Editor), Mast, Yvonne (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; Streptomyces; biogeography; comparative genomics; diversification; secondary metabolite biosynthetic gene clusters; SMGC; natural products; streptomyces; rishirilide; biosynthesis; polyketides; polynucleotide phosphorylase; ribonuclease; regulation; promoter; RNA decay; polyadenylation; (p)ppGpp; antibiotic; antibiotics; geomicrobiology; Illumina sequencing; microbiome diversity; Actinobacteria; Cave microbiology; secondary metabolite; rare Actinobacteria; Amycolatopsis; unculturability; siderophore; glycopeptide antibiotics; dbv cluster; regulatory genes; StrR; LAL; LuxR solo; dalbavancin; A40926; Streptomyces lividans; secretion pathways; secretory proteins; signal peptides; actinomycetes; teicoplanin; van resistance genes; Streptomyces tsukubaensis; tacrolimus; FK506; omics; screening; secondary metabolism; differentiation; elicitors; morphology; liquid cultures; metagenomics; rare actinomycetes; dereplication; metabolomics; genome mining; secondary metabolites; novel compounds; physicochemical screening; physical and chemical properties; structural diversity; biological activity; Actinoallomurus; antibiotics polyethers; lysolipin; minimal PKS II; cyclases; benz[a]naphthacene quinone; tridecaketide; aromatic polyketide; pentacyclic angular polyphenol; extended polyketide chain; actinobacteria; β-lactamase; resistance; β-lactamase inhibitor; polyketide synthases; acyltransferases; engineering; new bioactive compounds; symbiosis; drug discovery; chemical ecology; culture-based approaches; strain; specialized metabolites; biosynthetic gene cluster; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibi...