Periodontitis From Dysbiotic Microbial Immune Response to Systemic Inflammation

• Other Authors: Johansson, Anders (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; apical periodontitis; adaptive immunity; saliva; serum; antibody; Aggregatibacter actinomycetemcomitans; invasiveness; leukotoxin; cytolethal distending toxin; serum resistance; outer membrane vesicles; oral microbiome; nitric oxide; nitrate; nitrite; periodontal disease; alveolar bone loss; gingiva; bacteria; biofilm; immunity; inflammation; smoking; Rheumatoid arthritis; Porphyromonas gingivalis; periodontitis; citrullination; peptidylarginine deiminase; ACPA; anti-CCP; host response; infection; oral microbiota; virulence factors; metabolites; TREM-1; intervention; LP17; IL-17; RANKL; OPG; cardiovascular diseases; rheumatoid arthritis; inflammatory response
• Online Access: DOAB: download the publication; DOAB: description of the publication

Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate...