Cellular and Molecular Mechanisms in Pathogenesis of Multiple Sclerosis

• Other Authors: Wan, Edwin (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; neutrophils; lymphocytes; NLR; multiple sclerosis; disease activity; inside-out; outside-in; oligodendrocytosis; demyelination; gliosis; histology; top-down proteomics; bioinformatics; mitochondria; CD4+ T cells; memory T cells; autoimmune disease; effector memory T cell; central memory T cell; tissue-resident T cell; experimental autoimmune encephalomyelitis; monocytes; granulocyte-macrophage colony-stimulating factor; S100B; relapsing-remitting experimental autoimmune encephalomyelitis; pentamidine; NG2-glia; progenitors; lineage; in utero electroporation; morphometric analyses; clonal analyses; lesioned brain; sphingosine-1-phosphate receptors; glutamate synaptic dysfunction; microglia; T lymphocytes; experimental autoimmune encephalomyelitis (EAE); pro-inflammatory cytokines; neuroinflammation; ozanimod; AUY954; A971432; S1P1; S1P5; kynurenine pathway; kynurenic acid; oxidative stress; quinolinic acid; N-acetylserotonin; IDO; NAD+, multiple sclerosis; laquinimod; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Multiple sclerosis (MS) is one of the most common neurological disorders in young adults. The etiology of MS is not known, but it is generally accepted that it is autoimmune in nature. Our knowledge of the pathogenesis of MS has increased tremendously in the past decade through clinical studies and...