Radiolabelled Molecules for Brain Imaging with PET and SPECT

• Other Authors: Brust, Peter (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Research & information: general; Biology, life sciences; SV2A; SV2B; SV2C; microPET; [18F]UCB-H; epilepsy; PBIF; distribution volume; blocking assay; preclinical imaging; Alzheimer's disease (AD); network measure; graph theory; brain network; positron emission tomography (PET); persistent homology; Phosphodiesterase 2A (PDE2A); Positron Emission Tomography (PET); Benzoimidazotriazine (BIT); fluorinated; Mouse Liver Microsomes (MLM); cyclic nucleotide phosphodiesterase; PDE2A radioligand; nitro-precursor; fluorine-18; in vitro autoradiography; PET imaging; opioid receptors; positron emission tomography; radiotracers; μOR-, δOR-, κOR- and ORL1-ligands; movement disorders; pain; drug dependence; GBM; biomarkers; Sigma 1; Sigma 2; PD-L1; PARP; IDH; Alzheimer's disease; Parkinson's disease; β-amyloid plaques; neurofibrillary tangles; α-synucleinopathy; diagnostic imaging probes; orexin receptors; PET; radiotracer; imaging; alpha 7; nicotinic acetylcholine receptors; nAChR; autoradiography; amino acid; FET; FACBC; FDOPA; immunoPET; molecular imaging; glioma; brain metastases; adenosine A2A receptor; rotenone-based mouse model; [18F]FESCH; two-step one-pot radiosynthesis
• Online Access: DOAB: download the publication; DOAB: description of the publication

Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are lab...