Autophagy in Tissue Injury and Homeostasis

Autophagy ("auto-digestion"), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of...

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Bibliographic Details
Other Authors: Lin, Pei-Hui (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
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DOAB: description of the publication
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245 1 0 |a Autophagy in Tissue Injury and Homeostasis 
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520 |a Autophagy ("auto-digestion"), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on "Autophagy in Tissue Injury and Homeostasis", we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy. 
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650 7 |a Medicine  |2 bicssc 
653 |a aging 
653 |a dietary restriction 
653 |a acute kidney injury 
653 |a mitochondria 
653 |a autophagy 
653 |a mitophagy 
653 |a ischemia 
653 |a renal tubular cells 
653 |a diabetic nephropathy 
653 |a exosomes 
653 |a mTOR 
653 |a innate immunity 
653 |a immune cell 
653 |a inflammasome 
653 |a Paneth cell 
653 |a inflammatory bowel disease 
653 |a Crohn's disease 
653 |a hepatocytes 
653 |a hepatic stellate cells 
653 |a sinusoidal endothelial cells 
653 |a macrophages 
653 |a fibrosis 
653 |a cirrhosis 
653 |a hepatocellular carcinoma 
653 |a biomarkers 
653 |a cell death 
653 |a glutaminase 
653 |a metabolism 
653 |a molecular rehabilitation. 
653 |a kidney diseases 
653 |a oxidative stress 
653 |a inflammation 
653 |a ATGs 
653 |a intestinal homeostasis 
653 |a inflammatory bowel diseases 
653 |a HCC therapy 
653 |a Autophagy 
653 |a acute lung injury 
653 |a idiopathic pulmonary fibrosis 
653 |a COPD 
653 |a tuberculosis 
653 |a PAH 
653 |a cystic fibrosis 
653 |a Beclin-1 
653 |a cardiac dysfunction 
653 |a sepsis 
653 |a endotoxemia 
653 |a muscle regeneration 
653 |a stem cell 
653 |a immune 
653 |a macrophage 
653 |a senescence 
653 |a exercise 
653 |a caloric restriction 
653 |a diabetic retinopathy 
653 |a PINK1 
653 |a Notoginsenoside R1 
653 |a ethanol 
653 |a LC3 
653 |a apoptosis 
653 |a Sertoli cell 
653 |a Parkin 
653 |a TFEB 
653 |a infertility 
653 |a AMPK 
653 |a FOXO 
653 |a MTOR 
653 |a parkin 
653 |a spinal cord injury 
653 |a traumatic brain injury 
653 |a autophagic flux 
653 |a neuronal cell death 
653 |a lysosomal damage 
653 |a n/a 
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