Development of Humanized Mouse Models for Infectious Diseases and Cancer

• Other Authors: Tsuji, Moriya (Editor), Akkina, Ramesh (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2020
• Subjects: Medicine; Immunology; humanized mice in infectious disease research; humanized mice in cancer research; new humanized mouse models; humanized mice for HIV; malaria; vaccines and therapeutics; improved humanized mouse models
• Online Access: DOAB: download the publication; DOAB: description of the publication

While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre...