G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators

• Other Authors: Hattori, Yuichi (Editor), Michel, Martin C. (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2020
• Subjects: Science: general issues; Pharmacology; GRK; beta-arrestins; cardiovascular; inflammation; cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cell...