G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators
G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cell...
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Format: | Electronic Book Chapter |
Language: | English |
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Frontiers Media SA
2020
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Online Access: | DOAB: download the publication DOAB: description of the publication |
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100 | 1 | |a Hattori, Yuichi |4 edt | |
700 | 1 | |a Michel, Martin C. |4 edt | |
700 | 1 | |a Hattori, Yuichi |4 oth | |
700 | 1 | |a Michel, Martin C. |4 oth | |
245 | 1 | 0 | |a G Protein-Coupled Receptor Kinases (GRKs) and Beta-Arrestins: New Insights into Disease Regulators |
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506 | 0 | |a Open Access |2 star |f Unrestricted online access | |
520 | |a G protein-coupled receptor kinases (GRKs) and arrestins were initially identified as a pivotal player in the process of desensitization of agonist-activated G protein-coupled receptors (GPCRs). However, growing evidence suggests GRKs and arrestins fulfill a vital role in regulating a variety of cellular proteins involved in signal transduction independently of GPCRs. Thus, GRKs and arrestins can interact with non-GPCRs. GRKs and arrestins may directly affect functioning of non-GPCRs or indirectly regulate non-GPCR signaling. In addition, emerging evidence supports that changes in function and/or expression of GRKs and arrestins may be important in cardiovascular, inflammatory, metabolic, or cancer pathologies. A better understanding of the pathological roles of GRKs and arrestins would provide a basis for new therapeutic targets in different human diseases. | ||
540 | |a Creative Commons |f https://creativecommons.org/licenses/by/4.0/ |2 cc |4 https://creativecommons.org/licenses/by/4.0/ | ||
546 | |a English | ||
650 | 7 | |a Science: general issues |2 bicssc | |
650 | 7 | |a Pharmacology |2 bicssc | |
653 | |a GRK | ||
653 | |a beta-arrestins | ||
653 | |a cardiovascular | ||
653 | |a inflammation | ||
653 | |a cancer | ||
856 | 4 | 0 | |a www.oapen.org |u https://www.frontiersin.org/research-topics/7617/g-protein-coupled-receptor-kinases-grks-and-beta-arrestins-new-insights-into-disease-regulators |7 0 |z DOAB: download the publication |
856 | 4 | 0 | |a www.oapen.org |u https://directory.doabooks.org/handle/20.500.12854/73699 |7 0 |z DOAB: description of the publication |