Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

• Eará dahkkit: Ey, Elodie (Doaimmaheaddji), Bourgeron, Thomas (Doaimmaheaddji), Maria Boeckers, Tobias (Doaimmaheaddji), Kim, Eunjoon (Doaimmaheaddji), Han, Kihoon (Doaimmaheaddji)
• Materiálatiipa: Elektrovnnalaš Girjji oassi
• Giella: eaŋgalasgiella
• Almmustuhtton: Frontiers Media SA 2020
• Fáttát: Science: general issues; Neurosciences; Shank; Shankopathies; neuropsychiatric disorders; modulating factors; brain regions
• Liŋkkat: DOAB: download the publication; DOAB: description of the publication

Čoahkkáigeassu

Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.

Olgguldas hápmi

1 electronic resource (231 p.)

ISBN

978-2-88963-567-2
9782889635672

Beassan

Open Access