The Protein Alpha-Synuclein: Its Normal Role (in Neurons) and its Role in Disease

• Other Authors: Manfredsson, Fredric P. (Editor), Perez, Ruth G. (Editor), Martinez Sandoval, Ivette (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2020
• Subjects: Science: general issues; Neurosciences; alpha-synuclein function; alpha-synuclein aggregation; neurodegeneration; Parkinson's disease; synucleinopathies
• Online Access: DOAB: download the publication; DOAB: description of the publication

The protein alpha-synuclein (α-syn) is by far the most vetted pathogenic participant in the neurodegeneration that occurs in Parkinson's disease (PD) and other synucleinopathies such as multiple system atrophy (MSA). Although the precise role of this protein in disease pathogenesis is unknown,...