Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets

• Other Authors: Cassinelli, Giuliana (Editor), Lanzi, Cinzia (Editor), Alexander Yates, Edwin (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2020
• Subjects: Medicine; Oncology; heparan sulfate proteoglycan; heparanase; sulfotransferase; glypican; cancer therapy
• Online Access: DOAB: download the publication; DOAB: description of the publication

In recent decades, evidence has accumulated implicating heparan sulfate proteoglycans (HSPGs) in tumor initiation and progression. Ubiquitously present at the cell surface and in the extracellular matrix, HSPGs are composed of a protein core with covalently bound heparan sulfate (HS) chains. They pr...