Hereditary Hemorrhagic Telangiectasia Recent Advances and Future Challenges

• Autres auteurs: Mager, Hans-Jurgen (Éditeur intellectuel), Bernabeu, Carmelo (Éditeur intellectuel), Post, Marco (Éditeur intellectuel)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Sujets: Research & information: general; hereditary hemorrhagic telangiectasia; rare diseases; telangiectasis; transforming growth factor-beta (TGF-β); Smad pathway; gastrointestinal bleeding; epistaxis; nosebleeds; tacrolimus; nasal ointment; genetic disease; rare disease; hereditary hemorrhagic telangiectasia (HHT); telangiectases; mechanical damage; sun-induced trauma; vascular malformations; Endoglin; activin-receptor-like kinase 1; Hereditary Hemorrhagic Telangiectasia; antithrombotic therapy; anticoagulants; antiplatelets; bleeding; safety; HHT; ALK1; endoglin; raloxifene; bazedoxifene; tranexamic acid; propranolol; FK506; etamsylate; N-acetylcysteine; pulmonary arteriovenous malformations; transcatheter embolotherapy; screening; guidelines; Hereditary hemorrhagic telangiectasia; pediatrics; genotype-phenotype correlation; arteriovenous malformation; ENG; ACVRL1; SMAD4; microRNA; biomarker; plasma; arteriovenous malformations (AVMs); angiogenesis; activin receptor-like kinase 1 (ALK1); transforming growth factor beta (TGF-β); bone morphogenetic protein (BMP); propranolol gel; epistaxis severity score; nasal endoscopy; antiangiogenic properties; non-coding RNAs; microRNAs; long non-coding RNAs; biomarkers; endothelial cells; hereditary hemorrhagic telangiectasia (HHT), second-hit; arteriovenous malformation (AVM); Smad4; inflammation; shear stress; vascular injury; somatic mutation; cell adhesion; vascular endothelial growth factor (VEGF); telangiectasia; hereditary hemorrhagic; survival; life expectancy; pulmonary arteriovenous malformation; contrast enhanced magnetic resonance angiography; liver; MRI; ultrasound; AVM; bevacizumab; Osler-Weber-Rendu; hereditary hemorrhagic telangiectasia/HHT/osler's disease; cerebral ischemic lesions; catheter based embolization therapy
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lip...