Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations

• Other Authors: Ciarimboli, Giuliano (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; transporters; endogenous metabolism; functional subgroups; SLC22; remote sensing and signaling; drug transporters; gut microbiome; chronic kidney disease; solute carrier 22 (SLC22); Remote Sensing and Signaling Theory; interorgan communication; organic anion transporter; organic cation transporter; SLC22A15; SLC22A16; SLC22A18; kidney; Malpighian tubule; TCGA; human pathology atlas; gene ontology; organic cations; transport; kidneys; regulation; Nuclear receptor; renal excretion; bile acids; organic cation transporters; drug disposition; genetic polymorphisms; drug-induced kidney injury; nephrotoxicity; RA; Tofacitinib; Baricitinib; MATE1; solute carrier (SLC) family; OCT1; SLC22A1; species differences; drugs; pesticides; cisplatin nephrotoxicity; PPAR-alpha; organic transporters; serotonin transporter; plasma membrane monoamine transporter; ketamine; isoflurane; serotonin clearance; antidepressant-like activity; chronoamperometry; tail suspension test; forced swim test; hepatotoxicity; solute carrier; pulmonary drug delivery; SLC22A1-5; lung epithelium; drug uptake; β2-agonists; chronic lung diseases; anticholinergics; trospium; OCT; MATE; drug excretion; drug transport; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Membrane transporters are of vital importance for cells. They mediate the flux of many substances through the plasma membrane. In this book, the transporters for organic cations, a special class of membrane transporters, are presented. Transporters belonging to this class are important because they...