Insulin-Like Growth Factors in Development, Cancers and Aging

• Other Authors: Werner, Haim (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; IGF-I; IGF-II; insulin; IGF-IR; IRs; tyrosine kinase receptor; GPCRs; hybrids; phosphorylation; G-proteins; β-arrestins; functional RTK/GPCR hybrid; nuclear translocation; IGF-I receptor; signaling; targeted therapeutics; IGF-Trap; IGF system; IGFBP-3; IGFBP-3R; TMEM219; anti-tumor; anti-metastatic; agonists; mAb therapy; IGF-1; IGFBP-1; older adults; longevity; health-span; age-related disease; cognitive impairment; diabetes; mitochondria; growth hormone; insulin-like growth factor-1; aging; oxidative stress; senescence; longitudinal study; IGFBP; mouse models; skeletal muscle; MSCs; myogenesis; glucose regulated protein (GRP) 94; insulin-like growth factor; obligate chaperone; hypertrophy; atrophy; cachexia; muscle regeneration; autophagy; IGF-1R; insulin receptor; IR-A; structural studies; receptor activation; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

This Special Issue of Cells on "Insulin-Like Growth Factors in Development, Cancers and Aging" provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects...