Synthesis of Marine Natural Products and Molecules Inspired by Marine Substances

• Autres auteurs: Manzo, Emiliano (Éditeur intellectuel)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Sujets: Language; organic synthesis; meroterpenoids; thiazinoquinones; antiproliferative activity; G0/G1 cell-cycle arrest; cytostatic; solid tumor cell lines; alkylglycerol (AKG); ricinoleic acid (RA); antimicrobial activity; structure-activity relationship (SAR) studies; antibiotics (gentamicin; tetracycline; ciprofloxacin and ampicillin); marine-inspired; breast cancer; bis-indoles; synthesis; apoptosis; carbohydrates; polysaccharides; semi-synthesis; sulfation; glycosylation; fucose; fucosylated chondroitin sulfate; marine natural product; largazole; HDAC inhibitors; modification; fluoro olefin; total synthesis; natural product; 7-deazapurine nucleoside; disaccharide nucleoside; tubercidin; aureol; tetracyclic meroterpenoids; natural products synthesis; labdane scaffold; bioactive diterpenes; sclareolide; structure-activity relationships; TRPV4 channel; amides/esters; COVID-19; SARS-CoV-2; lipophilic iminosugars; polymer-supported triphenyl phosphine; cholesterol; antibacterial iminosugars; n/a
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

Marine natural products are characterized by high chemical diversity, biochemical specificity, and other molecular properties that make them favorable as lead structures for drug discovery. In this field, one of the main problems is often the reduced natural availability of isolated substances, whic...