Advances in DNA Vaccines

• Other Authors: Isaguliants, Maria (Editor), Ljungberg, Karl (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Medicine; Epidemiology & medical statistics; alphaviruses; layered RNA/DNA vectors; DNA vaccines; RNA replicons; recombinant particles; tumor regression; protection against tumor challenges and infectious agents; ebola virus disease; artificial T-cell antigens; DNA vaccine constructs; computer design; gene expression; immunogenicity; DNA vaccine; mRNA vaccine; plasmid DNA; in vitro transcribed mRNA; immune responses; formulations; Cytolytic T Lymphocytes; antibodies; innate immunity; adjuvants; vaccine delivery; plasmid; cytolytic; perforin; bicistronic; HCV; HIV; IL-36; adjuvant; DNA; Zika; Epstein-Barr virus; latent proteins; LMP2; EBNA1; LMP1; HIV-1; enhancer element; circovirus; influenza; immunization; intranasal; lipid; flagellin; BCG; vaccine; rBCG; HTI; T-cell; AIDS; clinical trial; therapeutic vaccine; hepatitis C virus (HCV); mesenchymal stem cells (MSC); modified MSC; DNA immunization; nonstructural HCV proteins; immune response; HCV vaccine; myeloid derived suppressor cells (MDSCs); n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

DNA is a rapidly developing vaccine platform for cancer and infectious and non-infectious diseases. Plasmids are used as immunogens to encode proteins to be further synthesized in vaccine recipients. DNA is mainly synthetic, ensuring enhanced expression in the cells of vaccine recipients (mostly mam...