Drug-Drug Interactions

• Other Authors: Kim, Dong Hyun (Editor), Lee, Sangkyu (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; tadalafil; ticagrelor; drug-drug interaction; pharmacokinetics; plasma concentration; CYP3A4; Loxoprofen; CYP3A; Dexamethasone; Ketoconazole; CYP2D6; O-desmethyltramadol; physiologically-based pharmacokinetics; tramadol; (‒)-sophoranone; CYP2C9; potent inhibition; in vitro; in vivo; drug interaction; low permeability; high plasma protein binding; biflavonoid; cytochrome P450; drug interactions; selamariscina A; uridine 5'-diphosphoglucuronosyl transferase; tissue-specific; systemic exposure; P-glycoprotein (P-gp); organic anion transporting polypeptide 1A2 (OATP1A2); Rumex acetosa; fexofenadine; chronic kidney disease; drug-drug interactions; polypharmacy; adverse drug reactions; Lexicomp; subset analysis; signal detection algorithms; spontaneous reporting systems; mechanism-based inhibition; competitive inhibition; non-competitive inhibition; substrate; inhibitor; cytochromes P450; OATP1B1; OATP1B3; tyrosine kinase inhibitors; migraine; lasmiditan; gepants; monoclonal antibodies; CYP1A1; CYP1A2; expression; metabolism; regulation; drug transporter; ubiquitination; ixazomib; DDI; computational prediction; in silico; QSAR; drug metabolism; ADME; CYP; metabolic DDI; P450; 1A2; 2B6; 2C19; 2C8; 2C9; 2D6; 3A4
• Online Access: DOAB: download the publication; DOAB: description of the publication

Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have bee...