Cellular Senescence in Health, Disease and Aging: Blessing or Curse?

• Other Authors: Riessland, Markus (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Subjects: Research & information: general; Biology, life sciences; γH2AX; Alzheimer's disease; DNA damage; mild cognitive impairment; senescence; secreted protein acidic and rich in cysteine; regeneration; homeostasis; cellular senescence; biology of aging; neurodegeneration; brain; geroscience; senolytics; tauopathy; cancer; stress response; post-mitotic; neuronal senescence; amyotrophic lateral sclerosis; senescence-associated secretory phenotype (SASP); cell-cycle; melanoma; pancreatic adenocarcinoma; tumor infiltration; chemotherapy resistance; prostate; inflammation; AIM2 inflammasome; POP3; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial role...