Drug Metabolism/Transport and Pharmacokinetics

• Outros Autores: Song, Im-Sook (Editor)
• Formato: Recurso Electrónico Capítulo de Livro
• Idioma: inglês
• Publicado em: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Assuntos: Medicine; Pharmaceutical industries; tofacitinib; dose-dependent pharmacokinetics; hepatic and intestinal first-pass effect; rats; catalposide; in vitro human metabolism; UDP-glucuronosyltransferase; sulfotransferase; carboxylesterase; celecoxib; drug-drug interaction; fluorescence; HPLC; metabolism; repaglinide; HSG4112; anti-obesity agent; stereoselectivity; pharmacokinetics; compound K; protopanaxadiol (PPD); biliary excretion; intestinal metabolism; Carthamus tinctorius extract; notoginseng total saponins; comparative pharmacokinetic study; large volume direct injection; compatibility mechanism; mertansine; human hepatocytes; cytochrome P450; UDP-glucuronosyltransferases; sodium-glucose cotransporter 2 (SGLT2) inhibitors; DWP16001; kidney distribution; inhibition mode; diabetes; transporter-enzyme interplay; influx transporter; efflux transporter; physiologically based pharmacokinetic model; cytochrome P450 enzymes; tiropramide; healthy Korean subjects; modeling; population pharmacokinetic; quercetin; breast cancer resistance protein; inhibitor; prazosin; sulfasalazine; kinetic analysis; food-drug interactions; Caco-2; EpiIntestinal; first-pass; P-gp; BCRP; drug transporter; CYP3A4; oral availability; automatization; drug absorption; drug dosing; head-and-neck cancer; real-time measurements; taxanes; tissue engineering; UHPLC-MS/MS; metformin; verapamil; drug interaction; organic cation transporter 2; renal excretion; acute renal failure; gentamicin; cisplatin; hepatic CYP3A1(23); creatinine clearance; renal clearance; nonrenal clearance
• Acesso em linha: DOAB: download the publication; DOAB: description of the publication

This book serves to highlight the pharmacokinetics/drug-drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic d...