Drug Absorption Studies: In Situ, In Vitro and In Silico Models

• Andere auteurs: Song, Im-Sook (Redacteur)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Onderwerpen: Medicine; Pharmaceutical industries; rebamipide; nanocrystals; oral mucositis; hydrogel; endocytosis; enoxaparin; lipid-polymer hybrid nanoparticles; oral; intestinal absorption; naftidrofuryl oxalate; solubility; permeability; dissolution profiles; pharmaceutical availability; BCS drug classification; non-sink condition; solubility-permeability interplay; unstirred water layer; poorly soluble drugs; solubilizer additive; phenylketonuria; l-phenylalanine ammonia-lyase; enzyme; kinetics; catabolism disorder; biomedical drug; P-glycoprotein; breast cancer resistance protein; LY335979; WK-X-34; in vivo-in vitro correlation; lipolysis-permeation; lipid-based drug delivery system; PermeaPad; cinnarizine; lipolysis; amorphous solid dispersion; candesartan Cilexetil; PVPK30; pH-modulation; spray drying; bioavailability; nasal administration; spray-drying; chitosan; microsphere; meloxicam; silymarin; D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS); liver distribution; acetaminophen-induced hepatotoxicity; extra virgin olive oil; secoiridoids; metabolism; phenolic compounds; intestinal permeability; drug-phytochemical interaction; hepatic metabolism; mixed inhibition; quercetin; repaglinide
• Online toegang: DOAB: download the publication; DOAB: description of the publication

This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorpt...