Coumarin and Its Derivatives

• Kolejni autorzy: Matos, Maria João (Redaktor)
• Format: Elektroniczne Rozdział
• Język: angielski
• Wydane: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021
• Hasła przedmiotowe: Research & information: general; Biology, life sciences; coumarin; hydroxyl-modified coumarin; photophysical; thermal and structural characterization; Glycyrrhiza uralensis; glycyrol; liquiritigenin; cholinesterases; human monoamine oxidases; kinetics; docking simulation; chalcone; neurodegenerative diseases; adenosine receptors; binding affinity; docking; 4-hydroxy-7-methoxycoumarin; macrophage; inflammation; NF-κB; MAPK; calanolides; pseudocalanolides; calanolide A; Calophyllum; Calophyllaceae; anti-HIV; reverse transcriptase; non-nucleoside reverse transcriptase inhibitors (NNRTIs); osthole; umbelliferone; esculin; 4-hydroxycoumarin; sorafenib; apoptosis; autophagy; Yin Chen Hao; constitutive androstane receptor; scoparone; coumarins; quorum sensing; QS inhibitors; plant-derived molecules; Chromobacterium violaceum; immunoproteasome; psoralen core; non-peptidic; electrophilic compounds; warhead scan; inflammatory bowel disease; isocoumarin; Crohn's disease; ulcerative colitis; glutathione; oxidative stress; complementary therapies; intestinal inflammation; benzopyrones; five-membered aromatic heterocycles; furan; pyrrole; thiophene; selenophen; dihydrocoumarin-fused dihydropyranones; 3-aroylcoumarines; benzyl 2,3-butadienoate; 6'-(4-biphenyl)-β-iso-cinchonine; biological applications; drug discovery; fluorescent probes; warfarin; acenocoumarol; mechanical valve; time in therapeutic range; anticoagulation; Ruta chalepensis; Rutaceae; chalepin; chalepensin; bioactivity; biosynthesis; coumarin3-carboxamides; pyranocoumarins; anticancer activity; antibacterial activity; free radical polymerization; LED; photocomposites; direct laser write; analytical methods; model plant; natural genetic variation; natural products; simple coumarins; chalcocoumarin; MAO-B; molecular dynamics; in silico studies; dye-sensitized solar cells; coumarin dyes; thieno [3,2-b] thiophene; charge transfer; ethynylaryl; esculetin; antiplatelet activity; impedance aggregometry; COX; polyphenols; pyrazole; imidazole; thiazole; oxazole; triazole; thiadiazole; curcumin; curcumin-coumarin hybrids; neuroprotection; monoamine oxidase inhibition; cholinesterase inhibition; scavenging activity; Escherichia coli; biotransformation; ferulenol; structural annotation; in silico tools; n/a
• Dostęp online: DOAB: download the publication; DOAB: description of the publication

Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extra...