Solid Dispersions for Drug Delivery Applications and Preparation Methods

• Other Authors: Khutoryanskiy, Vitaliy (Editor), Al-Obaidi, Hisham (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; Pharmaceutical industries; solid dispersions; drug delivery; biological applications; solid dispersion; delivery system; polymeric carriers; antichagasic activity; fexofenadine hydrochloride; PEG 20,000; poloxamer188; dissolution; absorption; green nanotechnology; raloxifene; nanoemulsion; core-sheath nanofibers; response surface methodology; ex vivo drug permeation; in vivo pharmacokinetic studies; acalabrutinib; amorphous solid dispersion; acid-reducing agent; bioavailability enhancement; kinase inhibitor; pH effect; proton pump inhibitor; spray drying; hydrogen bonding; hydrophobicity; poly(N-vinyl pyrrolidone); poly(2-oxazolines); crystallinity; hydrophobic drug; amorphous; ibuprofen; drug-rich phase; liquid-liquid phase separation; permeability enhancement; cocrystals; coamorphous; solubility; dry powder inhalers; pulmonary drug delivery; acid reducing agent; in silico prediction; absorption modeling; GastroPlus; paroxetine; nanosuspension; oral fast dissolving film; factorial design; rapid release; ex vivo permeation; bioavailability; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Since their first application in the improvement of solubility of orally delivered drugs, applications of solid dispersions have considerably expanded to include cancer, infections, and inflammatory conditions. This book presents recent advancements in the development and use of solid dispersions fo...