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Solid Dispersions for Drug Delivery Applications and Preparation Methods

Since their first application in the improvement of solubility of orally delivered drugs, applications of solid dispersions have considerably expanded to include cancer, infections, and inflammatory conditions. This book presents recent advancements in the development and use of solid dispersions fo...

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Bibliographic Details
Other Authors: Khutoryanskiy, Vitaliy (Editor), Al-Obaidi, Hisham (Editor)
Format: Electronic Book Chapter
Language:English
Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
Medicine
Pharmaceutical industries
solid dispersions
drug delivery
biological applications
solid dispersion
delivery system
polymeric carriers
antichagasic activity
fexofenadine hydrochloride
PEG 20,000
poloxamer188
dissolution
absorption
green nanotechnology
raloxifene
nanoemulsion
core-sheath nanofibers
response surface methodology
ex vivo drug permeation
in vivo pharmacokinetic studies
acalabrutinib
amorphous solid dispersion
acid-reducing agent
bioavailability enhancement
kinase inhibitor
pH effect
proton pump inhibitor
spray drying
hydrogen bonding
hydrophobicity
poly(N-vinyl pyrrolidone)
poly(2-oxazolines)
crystallinity
hydrophobic drug
amorphous
ibuprofen
drug-rich phase
liquid-liquid phase separation
permeability enhancement
cocrystals
coamorphous
solubility
dry powder inhalers
pulmonary drug delivery
acid reducing agent
in silico prediction
absorption modeling
GastroPlus
paroxetine
nanosuspension
oral fast dissolving film
factorial design
rapid release
ex vivo permeation
bioavailability
n/a
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Description
Summary:Since their first application in the improvement of solubility of orally delivered drugs, applications of solid dispersions have considerably expanded to include cancer, infections, and inflammatory conditions. This book presents recent advancements in the development and use of solid dispersions for different therapeutic applications. This book can be particularly useful for researchers as well as postgraduate students in formulation sciences and drug delivery. Undergraduate students will also find elements of this book very relevant to scientific fundamentals such as solubility and crystallization of amorphous materials as well as drug delivery challenges.
Physical Description:1 electronic resource (243 p.)
ISBN:books978-3-0365-2638-6
9783036526386
9783036526393
Access:Open Access

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