Colorectal Cancer From Pathophysiology to Novel Therapeutic Approaches

• Other Authors: Barresi, Valeria (Editor)
• Format: Electronic Book Chapter
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
• Subjects: Medicine; MSH2 3'UTR variant; hereditary colon cancer; Lynch syndrome; MSH2 protein; over expression MSH2; MMR gene; MMR complex deficiency; MSH2 unclassified variants; liquid biopsy; colorectal cancer; biomarkers; circulating tumor cells; circulating tumor DNA; genomic alterations; metastasis; tumor heterogeneity; tumor evolution; ADAM17; colorectal cancer (CRC); TNFα; IL-6R; AREG; shedding; regularized optimization; Cox regression; survival analysis; TCGA data; RNA-seq data; gut microbiota; colorectal adenoma; polyps; bacteria; monoclonal antibody; therapeutic target; therapy; colon cancer; poorly differentiated clusters; prognostic factors; inflammatory markers; histopathological markers; immune system; colorectal surgery; nanofibrous materials; anastomotic leakage; intestinal anastomosis; anastomotic patch; polycaprolactone; electrospinning; experiment; peritoneal adhesions; CRC; CTC; ctDNA; mi-RNA; nc-RNA; differentially expressed genes; cancer stem cells; qPCR; chemoresistance; TRIM8; miR-17-5p; PDX; patient-derived xenograft; omega-3 fatty acids; n/a
• Online Access: DOAB: download the publication; DOAB: description of the publication

Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of th...